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Short Report
Latin American experience with blood component’s quality control obtained by buffy coat method
1 Product Specialist, Macopharma do Brasil, Brazil
2 Senior Medical Department, Macopharma, Tourcoing, France
3 Medical Department Director, Macopharma, Tourcoing, France
4 Head of Blood Bank, UMAE Hospital de Especialidades, Puebla, Mexico
5 Quality Control Coordinator Blood Bank, UMAE Hospital de Especialidades, Puebla, Mexico
6 Subdirector Technician, Centro de Sangre Valparaíso, Chile
7 Production Coordinator, Centro de Sangre Valparaíso, Chile
8 Blood Bank Director, Banco de Sangre de Córdoba, Montería, Colombia
9 Production Coordinator, Banco de Sangre de Córdoba, Montería, Colombia
10 Quality Control Coordinator, Banco de Sangre de Córdoba, Montería, Colombia
Address correspondence to:
Dalia María Moreno Cardona
Calle 45D No. 81-10 apto 1501, Medellín, Antioquia,
Pin- 50031, Colombia
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Article ID: 100055Z02DM2020
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Cardona DMM, Frontier L, Álvarez I, Ibarra Y, Morales Y, Alvarado A, Martínez K, Cristancho N, Rolón M, Hernández Z. Latin American experience with blood component’s quality control obtained by buffy coat method. Int J Blood Transfus Immunohematol 2020;10:100055Z02DM2020.ABSTRACT
Aims: To explore the compliance with European standards for the quality control (QC) parameters of blood components production in Latin American blood banks, evaluating QC data results processed with red blood cell (RBC), and platelet concentrates (PL) produced.
Methods: An observational retrospective cross-sectional study was conducted with data from one year’s production QC data of platelet concentrate (PL) from the buffy-coat (BC) removal method. Red blood cell was collected in three blood banks from Mexico, Colombia, and Chile. Analysis of the quality limits established in each country was made using Pearson’s Chi-square test. Dunnett’s T3 test evaluated the comparative analysis of the mean. All the tests were performed with bilateral contrast, achieving statistical significance when p ≤ 0.05.
Results: The mean of the total results for the RBC evaluated was volume 277 mL ± 21; hematocrit (HCT) 58.7% ± 3.6; leukocytes (×109/mL) 0.47 ± 0.31. Results for PL were volume: 67 ± 10; platelet count (×109/mL): 76.8 ± 24; leukocytes (×109/mL) 0.02 ± 0.02. According to these total results, the compliance with respect to the control performed was for RBC: Volume 97.9%; hematocrit 98.8%; leukocytes 97%. For PL was 100% for volume; platelet count 82.3%; leukocytes 95.3%.
Conclusion: The QC results conclude that the RBC with the BC removal process produces high-quality components, with a reduced concentration of leukocytes, complying with European Union (EU) guidelines and allow to obtain single platelet from BC with high quality.
Keywords: Blood bank, Latin America, Platelets concentrate, Quality control, Red cell concentrates
SUPPORTING INFORMATION
Acknowledgments
We thank the three participating centers, which have worked for several years with the assembly of the quality control program, and continued to do so to guarantee the stability of their procurement process of blood production.
Author ContributionsDalia María Moreno Cardona - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Ludwig Frontier - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Ignacio Álvarez - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Yolanda Ibarra - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Yazmín Morales - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Alicia Alvarado - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Karin Martínez - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Nohora Cristancho - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Mary Rolón - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Zuly Hernández - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2020 Dalia María Moreno Cardona et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
