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Case Report
IgG4-related inflammatory pseudotumor of the liver presenting as an incidental solitary liver mass
1 Department of Surgery, Section of Hepatobiliary and Transplantation Surgery, King Faisal Specialist Hospital and Research Centre, Jeddah, Saudi Arabia
2 Department of Radiology, King Faisal Specialist Hospital and Research Centre, Jeddah, Saudi Arabia
3 Department of Medicine, King Faisal Specialist Hospital and Research Centre, Jeddah, Saudi Arabia
4 Department of Anatomic Pathology, King Faisal Specialist Hospital and Research Centre, Jeddah, Saudi Arabia
5 Departmet of Surgery, Section of Hepatobiliary and Transplantation Surgery, King Faisal Specialist Hospital and Research Centre, Jeddah, Saudi Arabia
Address correspondence to:
Niaz Ahmad
MD, FRCS, Department of Surgery, Section of Transplantation & HPB Surgery, King Faisal Specialist Hospital and Research Centre, PO Box 40047, Jeddah 21499,
Saudi Arabia
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Article ID: 100101Z04MM2023
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How to cite this article
Mirghani MO, Zia Z, Mawardi MH, Almansouri Z, Ahmad N. IgG4-related inflammatory pseudotumor of the liver presenting as an incidental solitary liver mass. Int J Hepatobiliary Pancreat Dis 2023;13(1):1–6.ABSTRACT
Inflammatory pseudotumor is increasingly being recognized as a definitive pathological entity affecting many organ systems and often difficult to distinguish from malignancy. We report a case of a 48-year-old female who presented with right hypochondrial pain associated with nausea and vomiting and recent weight loss. An ultrasound scan demonstrated gallstones without evidence of cholecystitis and an incidental 1.5 cm mass in the left liver lobe. A computed tomography (CT) and a magnetic resonance imaging (MRI) scan described the mass suspicious of a malignant tumour. An ultrasound-guided biopsy confirmed a benign inflammatory mass with lymphoplasmacytic infiltration staining for IgG4 and no evidence of malignancy. The patient had an elevated serum IgG4 levels. The patient was kept under surveillance. She underwent a laparoscopic cholecystectomy and at 18 months following the initial presentation the patient remains asymptomatic with stable liver lesion on ultrasound scan.
Keywords: Inflammatory pseudotumor, IgG4, Liver, Plasma cell
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Author Contributions
Mohammed Omer Mirghani - Acquisition of data, Drafting the work, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Zergham Zia - Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Mohammad Haytham Mawardi - Conception of the work, Design of the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Zuhoor Almansouri - Acquisition of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Niaz Ahmad - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2023 Mohammed Omer Mirghani et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
