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Research Article
Cytokines profile in occult hepatitis B virus infections in blood donors at the National Blood Transfusion Center of Lomé, Togo
1 National Blood Transfusion Center (CNTS), Lomé, Togo
2 Department of of Basic Sciences, Faculty of Health Sciences, Lomé, Togo
3 Higher School of Biological and Food Techniques (ESTBA)-UL, Lomé, Togo
Address correspondence to:
Liza Koboyo Nadjir
BP: 4090, Lomé,
Togo
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Article ID: 100084Z02LN2024
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Nadjir LK, Katawa G, Amessoudji M, Kolou M, Feteke L. Cytokines profile in occult hepatitis B virus infections in blood donors at the National Blood Transfusion Center of Lomé, Togo. Int J Blood Transfus Immunohematol 2024;14(2):1–6.ABSTRACT
Aims: Occult hepatitis B infection (OBI) was detected in blood donors at the National Blood Transfusion Center (CNTS) of Lomé. This constitutes a risk of transmission of the OBI to transfused patients since the detection of this infection is not systematic. The aim of this study is to describe the profile of cytokines in blood donors with OBI at CNTS of Lomé in Togo.
Methods: This is a prospective study during which the cytokines IL-6, TNFα, IL-5, IL-10, IL-17A, and IFNγ were measured by using a sandwich enzyme-linked immunosorbent assay (ELISA) at two time points: initially (D0) in August 2022 and again seven months later (+7 months) in April 2023, in blood donors with occult hepatitis B infection.
Results: At D0, the cytokine profile in sera of occult hepatitis B donors showed a significant reduced level of IL-6 (p=0.0009), TNFα (p=0.0025), IL-5 (p=0.0011), and IL-17A (p=0.0218) compared to non-occult hepatitis B donors. The inflammatory cytokine IFNγ and the regulatory cytokine IL-10 were also reduced but the differences were not significant. After seven months, the sera cytokine profile of occult hepatitis B donors had not changed, showing a significant reduced level of IL-6 (p=0.0005), TNFα (p<0.0001), IL-5 (p=0.0234), and IL-17A (p<0.0001). We noticed especially for IL-17A, undetectable levels.
Conclusion: Several authors have highlighted the presence of inflammatory cytokines in their studies; however, in our study, we noticed a downregulation or an absence of inflammatory cytokines in donors with occult hepatitis B.
Keywords: Blood donors, Lomé, OBI
SUPPORTING INFORMATION
Acknowledgments
Immunology and immunomodulation research unit (UR2IM), Higher School of Biological and Food Techniques (ESTBA)-UL, Lome, Togo
Author ContributionsLiza Koboyo Nadjir - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Gnatoulma Katawa - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Marthe Amessoudji - Acquisition of data, Analysis of data, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Maléwé Kolou - Drafting the work, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Lochina Feteke - Conception of the work, Design of the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2024 Liza Koboyo Nadjir et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
