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Research Article
Ferritin level in sickle cell patients at the sickle cell referral center of Lomé in 2022
1 Hematology Department, University of Lomé, Togo
2 Sickle Cell Disease Referral Center of Lomé, Togo
3 Hematology Department, University of Kara, Togo, Togo
4 Biochemistry Department, Université of Lomé, Togo
Address correspondence to:
Magnang Hèzouwè
Hematology Department, University of Lomé,
Togo
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Article ID: 100082Z02MH2024
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Hèzouwè M, Koffi M, Corcellar WKM, Irénée KMD, Yao L, Essohana P, Lochina F. Ferritin level in sickle cell patients at the sickle cell referral center of Lomé in 2022. Int J Blood Transfus Immunohematol 2024;14(1):5–10.ABSTRACT
Aim: Major sickle cell sufferers residing in tropical regions find themselves at the crossroads of several situations that can modify their iron status. Our aim was to describe ferritin levels in sickle cell patients at Centre National de Recherches et de Soins aux Drépanocytaires (CNRSD) of Lomé.
Methods: This was a cross-sectional study of sickle cell patients seen in medical consultations from May 16 to July 15, 2022. We included all sickle cell patients with anemia, who were seen in a medical monitoring during the study period and who gave their free consent. MINDRAY automatic system BC 6000, Mini-Vidas automatic system from BIOMERIEUX, and Minicap Flex Piercing from SEBIA were used to perform hemograms, ferritin levels, protidograms, and hemoglobin electrophoresis, respectively. The variables studied were patients’ medical history, age, sex, hematimetric indices, ferritin levels, hemoglobin fractions, and protidograms. We used Statistical Package for the Social Sciences (SPSS) software to analyze data.
Results: 117 patients with a mean age of 15.42±11.11 years were included. The sex ratio M/F was 0.98. Ferritin levels was below 15 ng/mL in 4 (3.42% of cases) and below 30 ng/mL in an inflammatory context in 7 patients (5.98%). Median ferritin level was 178.37 ng/mL; [Q1=59.39; Q3=411.35]. SS patients were most frequent (75.21%). The mean hemoglobin level of patients was 8.10±1.21 g/dL. Non-microcytic anemia was most frequent (57.30%).
Conclusion: Elevated ferritin levels were more frequent than iron deficiency in sickle cell patients at the CNRSD of Lomé. Thus, any prescription of iron should be motivated by proof of the existence of iron deficiency.
Keywords: Ferritin level, Iron status, Sickle cell patient, Togo
SUPPORTING INFORMATION
Author Contributions
Magnang Hèzouwè - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Mawussi Koffi - Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Womey Kodzovi Mawulé Corcellar - Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Kuéviakoé Messanh Délagnon Irénée - Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Layibo Yao - Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Padaro Essohana - Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Fétéké Lochina - Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2024 Magnang Hèzouwè et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
