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Research Article
Seroprevalence of transfusion transmissible infections among sickle cell anemia patients in Jos, North Central Nigeria
1 Department of Haematology and Blood Transfusion, Jos University Teaching Hospital, Jos, Nigeria
2 Department of Human Physiology, Faculty of Medical Sciences, University of Jos, Jos, Nigeria
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E D Jatau
Lecturer/Consultant Haematologist, Department of Haematology and Blood Transfusion, College of Health Sciences/Jos University Teaching Hospital, Jos,
Nigeria
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Article ID: 100052Z02EJ2020
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How to cite this article
Jatau ED, Egesie OJ, Damulak OD, Oyekemi A, Jasini J, Okeke CN, Ayuba Z, Adeyemi OA, Akor EA, Egesie UG. Seroprevalence of transfusion transmissible infections among sickle cell anemia patients in Jos, North Central Nigeria. Int J Blood Transfus Immunohematol 2020;10:100052Z02EJ2020.ABSTRACT
Aims: This study was aimed at determining the seroprevalence of some common transfusion transmissible viral infections in sickle cell anemia patients attending our adult hematology clinic for qualitative management.
Methods: A total of 111 sickle cell anemia patients attending the Hematology Outpatient Clinic (HOPC) of the Jos University Teaching Hospital (JUTH) in steady state were enrolled consecutively in this cross-sectional study irrespective of their blood transfusion status. Relevant demographic information and clinical histories were obtained using a structured questionnaire after obtaining informed consent from the subjects. Ethical approval was also obtained from the Institutions Human Research Ethics Committee. Blood sample was collected for complete blood count using a 3-part Sysmex hematology autoanalyzer, confirmatory hemoglobin electrophoresis and viral antigen/antibody screening using ELISA kits. Data was analyzed using Epi Info version 7.2.0.1 and Microsoft Office Excel version 2010.
Results: Majority of our subjects were within the age range of 18–30 years, 48 (43.2%) males and 63 (56.8%) females. Seventy-six (68.5%) had blood transfusion while 35 (31.5%) never had blood transfusion in their life. Seroprevalence of human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) among the transfused sickle cell anemia patients in this study was 7.9% for HIV, 22.4% for HBV, and 15.8% for HCV while those not transfused had seroprevalence of 8.6% for HIV and 11.4% for both HBV and HCV, respectively. No statistically significant difference was observed between those transfused and those who have not had blood transfusion in their life.
Conclusion: Seroprevalence of transfusion transmissible viral infections was relatively high and blood transfusion did not significantly influence the rate of these viral infections in our sickle cell anemia patients. Improved blood screening techniques, provision of antiviral medications, and vaccines at affordable cost are advocated.
Keywords: Jos, Seroprevalence, Sickle cell anemia, Transfusion transmissible infections
SUPPORTING INFORMATION
Acknowledgments
We thank staff and management of the Jos University Teaching Hospital (JUTH), Jos and National Blood Transfusion Services, Jos Zonal Office for their support.
Author ContributionsE D Jatau - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
O J Egesie - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
O D Damulak - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
A Oyekemi - Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
J Jasini - Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
C N Okeke - Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Z Ayuba - Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
O A Adeyemi - Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
E A Akor - Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
U G Egesie - Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2020 E D Jatau et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
