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Research Article
Endocrine complications of beta-thalassemia major patients—Cross-sectional study
1 Lecturer, Department of Basic Sciences, Faculty of Allied Health Sciences, General Sir John Kotelawala Defense University, Ratmalana, Sri Lanka
2 Professor, Department of Biochemistry, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka
3 Professor, Department of Pediatrics, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka
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Attanayaka Mudiyanse Dilhara Sewwandi Karunaratna
Department of Basic Sciences, Faculty of Allied Health Sciences, General Sir John Kotelawala Defense University, Postal Code CO10390, Ratmalana,
Sri Lanka
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Article ID: 100051Z02AK2020
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Karunaratna AMDS, Ranasingha JGS, Mudiyanse RM. Endocrine complications of betathalassemia major patients—Cross-sectional study. Int J Blood Transfus Immunohematol 2020;10:100051Z02AK2020.ABSTRACT
Aims: To evaluate the prevalence of endocrine complications in beta thalassaemia major patients in one of thalassaemia treatment units in Sri Lanka.
Methods: The patients (n = 40) aged >2 years admitted to the Teaching Hospital Peradeniya during the period of December 2013 to December 2014, under the treatment of iron chelation drugs were recruited for the study. The patients were interviewed for the sociodemographic variables and the data regarding endocrine complications were gathered from medical records. Anthropometric (height and weight) measurers and pubertal status were assessed by a qualified medical officer. The data were statistically analyzed by SPSS version 21.
Results: The mean age of the patients was 10.97±5.9 years (range 2–20). The most common endocrine complication was a pubertal delay (53%). The prevalence of short stature, hypothyroidism, diabetes mellitus, and hypoparathyroidism were 50%, 10%, 5%, and 2.5%, respectively. All the patients with endocrine complications were older children (>10-year-olds). Conclusion: Endocrine complications were common among the studied group of betathalassaemia major patients and it is related to progression of age. Regular assessment of endocrine function is imperative in the proper management of beta-thalassemia major patients.
Keywords: Beta-thalassemia major, Endocrine complications, Short stature
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Acknowledgments
We would like to thank Mr. JMNS Nawaratna, Mr. CN Perera, AMPSTM Bandara, and Mrs. PC Rajakaruna for their assistance in sample collection and laboratory analysis. Further our thanks go to Director and staff members of Peradeniya Teaching Hospital.
Author ContributionsAttanayaka Mudiyanse Dilhara Sewwandi Karunaratna - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Jamburagoda Gamage Shirani Ranasingha - Conception of the work, Design of the work, Analysis of data, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Rasnayaka Mudiyanselage Mudiyanse - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2020 Attanayaka Mudiyanselage Dilhara Sewwandi Karunara. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
