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Review Article
 
Induced pluripotent stem cells: An update
Anubha Singh1, Deepak Kumar Singh2, Usha Bhoria3
1Senior Resident, Department of Laboratory Services, Employees' State Insurance Corporation Model Hospital, Ministry of Labor, Noida, Uttar Pradesh, India.
2Junior Specialist, Department of Laboratory Services, Employees' State Insurance Corporation Model Hospital, Ministry of Labor, Noida, Uttar Pradesh, India.
3Senior Specialist, Department of Laboratory Services, Employees' State Insurance Corporation Model Hospital, Ministry of labor, Noida, Uttar Pradesh, India.

Article ID: 100016IJBTIAS2015
doi:10.5348/ijbti-2015-16-RA-2

Address correspondence to:
Anubha Singh
Senior Resident, Department of Laboratory Services, Employees' State Insurance Corporation Model Hospital
Noida, Uttar Pradesh
India

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How to cite this article
Singh A, Singh DK, Bhoria U. Induced pluripotent stem cells: An update. Int J Blood Transfus Immunohematol 2015;5:6–13.


Abstract
Introduction: The discovery that the mature cells can be reprogrammed to become pluripotent increased the enormous interest in induced pluripotent stem cell (iPSC) technology for their potential application in biomedical sciences. The breakthrough research offering induction of pluripotent status in somatic cells by direct reprogramming depends upon the genes used for induction. The induced pluripotent stem cells share features with embryonic stem cells such as pluripotency and immortality. The iPSC technology opened new avenues and provided vast opportunities for regenerative therapy and therapeutic drug development. This review summarizes the developments in iPSC technology highlighting the generation of iPSCs from blood as a source, which is a very important finding, alleviating the need for more invasive techniques such as skin punch biopsies.

Keywords: Induced pluripotent stem cell (iPSC), Reprogramming, Hematopoietic cells, Peripheral blood


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Author Contributions
Anubha Singh – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Deepak Kumar Singh – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Usha Bhoria – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of submission
The corresponding author is the guarantor of submission.
Source of support
None
Conflict of interest
Authors declare no conflict of interest.
Copyright
© 2015 Anubha Singh et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.