Index Copernicus IC Value: 83.92
International Journal of Blood Transfusion and Immunohematology - IJBTI - Review Articles, Original Articles, Short Communication, Case Series, Case Reports, Letter to Editors
 
     
Original Article
 
Shortened antibody screening interval has decreased the incidence of delayed hemolytic transfusion reactions
Nozomi Takano1, Hiroyasu Yasuda1, Masami Kikuchi1, Kinuyo Kawabata1, Chikako Takeuchi-Baba1, Satoshi Ono1, Takako Ono1, Keiji Minakawa1, Akiko Sugawara1, Saori Miura1, Kazuya Watanabe1, Maiko Abe1, Hiroe Suzuki1, Mao Watanabe1, Mutsumi Sasaki1, Kazuhiko Ikeda1, Kenneth E. Nollet1, Hitoshi Ohto1,2
1Department of Blood Transfusion and Transplantation Immunology, Fukushima Medical University Hospital, Fukushima, Japan
2Department of Advanced Cancer Immunotherapy, Fukushima Medical University, Fukushima, Japan

Article ID: 100042Z02NT2018
doi: 10.5348/100042Z02NT2018OA

Corresponding Author:
Hitoshi Ohto, MD, PhD
Department of Blood Transfusion and Transplantation Immunology
Fukushima Medical University School of Medicine
Fukushima City, Fukushima 960-1295, Japan

Access full text article on other devices

  Access PDF of article on other devices

[HTML Full Text]   [PDF Full Text] [Print This Article]
[Similar articles in PubMed] [Similar articles in Google Scholar]



How to cite this article
Takano N, Yasuda H, Kikuchi M, Kawabata K, Takeuchi-Baba C, Ono S, Ono T, Minakawa K, Sugawara A, Miura S, Watanabe K, Abe M, Suzuki H, Watanabe M, Sasaki M, Ikeda K, Nollet KE, Ohto H. Shortened antibody screening interval has decreased the incidence of delayed hemolytic transfusion reactions. Int J Blood Transfus Immunohematol 2018;8:100042Z02NT2018.


ABSTRACT

Aims: To ascertain the effects of allowable sampling time prior to red cell transfusion when screening for alloantibodies, we compared antibody detection rates and frequencies of delayed hemolytic transfusion reactions (DHTRs) among patients drawn within two weeks versus patients drawn within one week of transfusion.

Methods: Alloantibody screening for 32,601 patients from January 1997 through August 2006 was done within two weeks of transfusion, and for 44,896 patients from September 2006 through March 2017 was done within one week. Among transfusion recipients, 6,234 screened within two weeks and 8,066 screened within one week were evaluated for DHTR.

Results: Alloantibodies were detected in 1.2% of cases screened within two weeks and in 1.3% of cases screened within one week, with no statistical difference. Anti-Fyb was more frequently detected (115.8 versus 39.9 per 100,000 patients) among those screened within one week (p <0.001); anti-Dia showed a similar trend, but without statistical significance (p =0.065), whereas anti-c was less frequently detected (p <0.05). The number of DHTRs observed was significantly lower among those screened within one week, with two cases (1 in 4,031) versus eight (1 in 779) among those screened within 2 weeks (p <0.05).

Conclusion: By shortening allowable sampling period for red cell alloantibody screening from within two weeks to within one week of transfusion, the detection rate of clinically significant antibodies, except for anti-c, increased, and the frequency of DHTR recipients decreased.

Keywords: Alloantibody, Clinically significant antibody, Delayed hemolytic transfusion reaction, Irregular antibody screening


[HTML Full Text]   [PDF Full Text]

Author Contributions
Nozomi Takano – Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Hiroyasu Yasuda – Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Masami Kikuchi – Acquisition of data, Drafting the article, Final approval of the version to be published
Kinuyo Kawabata – Acquisition of data, Analysis and interpretation of data, Drafting the article, Final approval of the version to be published Chikako Takeuchi-Baba – Acquisition of data, Drafting the article, Final approval of the version to be published
Satoshi Ono – Acquisition of data, Drafting the article, Final approval of the version to be published
Takako Ono – Acquisition of data, Drafting the article, Final approval of the version to be published
Keiji Minakawa – Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Akiko Sugawara – Acquisition of data, Drafting the article, Final approval of the version to be published
Saori Miura – Acquisition of data, Drafting the article, Final approval of the version to be published
Kazuya Watanabe – Acquisition of data, Drafting the article, Final approval of the version to be published
Maiko Abe – Acquisition of data, Drafting the article, Final approval of the version to be published
Hiroe Suzuki – Acquisition of data, Drafting the article, Final approval of the version to be published Mao Watanabe – Acquisition of data, Drafting the article, Final approval of the version to be published
Mutsumi Sasaki – Acquisition of data, Drafting the article, Final approval of the version to be published
Kazuhiko Ikeda – Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Kenneth E. Nollet – Acquisition of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Hitoshi Ohto – Substantial contributions to conception and design, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of Submission
The corresponding author is the guarantor of submission.
Source of Support
None
Consent Statement
Written informed consent was obtained from the patient for publication of this original article.
Conflict of Interest
Author declares no conflict of interest.
Copyright
© 2018 Nozomi Takano et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.



  Terms of Service line Privacy policy line Disclaimer line FAQ line Contact: Journal line Contact: Edorium Journals line Site Map  
  Copyright © 2018. Edorium. All rights reserved.