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Serosurvey of human T cell lymphotropic virus I/II among blood donors in Gombe (Nigeria)
Mohammed Mohammed Manga1, Adeola Fowotade2, Saleh Yuguda3, Girei Ahmed Iya4, Mohammed Yahaya5, Yakubu Munkaila Sheriff6, Omoruyi Ewean Chukwuma7, Ibrahim Musa Yola8, Rasheed Ajani Bakare9
1MBBS, Lecturer and Consultant, Department of Medical Microbiology and Immunology, Federal Teaching Hospital Gombe, Gombe state Nigeria.
2MBBS, MSc Medical Virology, Lecturer and Consultant, Department of Medical Microbiology and Parasitology, University College Hospital Ibadan, Oyo state Nigeria.
3MBBS, Lecturer and Consultant, Department of Haematology, Federal Teaching Hospital Gombe, Gombe state Nigeria.
4MBBS, Consultant, Department of Haematology, Federal Teaching Hospital Gombe, Gombe state Nigeria.
5MBBS, Lecturer and Consultant, Department of Medical Microbiology and Parasitology, Usmanu Danfodio Univeristy Sokoto, Sokoto state Nigeria.
6BSc, Assistant Director Laboratory Services, Department of Haematology, Federal Teaching Hospital Gombe, Gombe state Nigeria.
7BSc, Institute of Child Health, College of Medicine University of Ibadan, Oyo state Nigeria.
8MBBS, Lecturer and Consultant, Department of Medicine, Federal Teaching Hospital Gombe, Gombe state Nigeria.
9MBBS, Professor and Consultant, Department of Medical Microbiology and Parasitology, University College Hospital Ibadan, Oyo State Nigeria.

Article ID: 100024IJBTIMM2016
doi:10.5348/ijbti-2016-24-OA-4


Address correspondence to:
Dr Mohammed M. Manga
Department of Medical Microbiology and Immunology
Federal Teaching Hospital, Ashaka road
PMB 037, Gombe State
Nigeria

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How to cite this article
Manga MM, Fowotade A, Yuguda S, Iya GA, Yahaya M, Sheriff YM, Chukwuma OE, Yola IM, Bakare RA. Serosurvey of human T cell lymphotropic virus I/II among blood donors in Gombe (Nigeria). Int J Blood Transfus Immunohematol 2016;6:12–19.


Abstract
Aim: This study was carried out to determine the prevalence of human T cell lymphotropic virus I/II (HTLV I/II) among blood donors at the Federal Teaching Hospital Gombe (FTHG), North-eastern, Nigeria.
Methods: A total of 355 blood donors were recruited at the hematology department of FTHG for a hospital based cross-sectional study and were screened/confirmed for HTLV I/II by ELISA and western blot methods.
Results: Seroprevalence of HTLV I/II among the 355 participants with mean age of 30.77 years (±8.27) was 6.5% on screening with ELISA but confirmed to be 0% by western blot. Majority were males, 352 (99.2%) and mostly (45.9%) between 21–30 years of age. Donors for family replacements predominated (85.1%) with more than half (58.6%) being first time blood donors.
Conclusion: This study reveals the absence of HTLV I/II among blood donors in Gombe North-eastern Nigeria. It also highlights the possibility of false positivity in some of the reported prevalence of HTLV I and II from some parts of Nigeria that were based on screening tests only. The importance of confirmatory testing in all research works on HTLV (including HTLV 3 and HTLV 4) is further strengthened with this study. There is however the need for a larger study and the use of molecular diagnostics to reconfirm this assertion.

Keywords: Blood donors, Gombe, Human T cell lymphotropic virus I/II (HTLV I/II), Nigeria, T cell


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Author Contributions:
Mohammed Mohammed Manga – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Adeola Fowotade, Yuguda Saleh – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Saleh Yuguda – Substantial contributions to conception and design, Acquisition of data, Revising it critically for important intellectual content, Final approval of the version to be published
Girei Ahmed Iya – Acquisition of data, Revising it critically for important intellectual content, Final approval of the version to be published
Mohammed Yahaya – Analysis and interpretation of data, Drafting the article, Final approval of the version to be published
Yakubu Munkaila Sheriff – Acquisition of data, Revising it critically for important intellectual content, Final approval of the version to be published
Omoruyi Ewean Chukwuma – Acquisition of data, Revising it critically for important intellectual content, Final approval of the version to be published
Ibrahim Musa Yola – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Rasheed Ajani Bakare – Substantial contributions to conception and design, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of submission
The corresponding author is the guarantor of submission.
Source of support
None
Conflict of interest
Authors declare no conflict of interest.
Copyright
© 2016 Mohammed Mohammed Manga et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.



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