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International Journal of Blood Transfusion and Immunohematology - IJBTI - Review Articles, Original Articles, Short Communication, Case Series, Case Reports, Letter to Editors
 
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Original Article
 
Prevalence of weak D phenotype among D negative C/E+ blood donors in Morocco
Mariam EL Wafi1, Houria EL Housse1, Nadia Nourichafi2, Kamal Bouisk2, Mohamed Benajiba3, Norddine Habti1,3,4
1Laboratory of Biotechnology and Experimental Medicine – Faculty of Medicine and Pharmacy Casablanca – Hassan II University of Casablanca.
2Regional Blood Transfusion Center in Casablanca.
3National Blood Transfusion and Hematology Center.
4Laboratory of Hematology, Cellular and Genetic Engineering – Faculty of Medicine and Pharmacy Casablanca – Hassan II University of Casablanca, Morocco.

Article ID: 100022IJBTITO2016
doi:10.5348/ijbti-2016-22-OA-2


Address correspondence to:
M. EL Wafi
Laboratory of Biotechnology and Experimental Medicine
Faculty of Medicine and Pharmacy, University Hassan II, 19 Rue Tarik Ibnou Ziad
B.P. 9154, Casablanca, 20000
Morocco

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How to cite this article
EL Wafi M, EL Housse L, Nourichafi N, Bouisk K, Benajiba M, Habti N. Prevalence of weak D phenotype among D negative C/E+ blood donors in Morocco. Int J Blood Transfus Immunohematol 2016;6:3–7.


Abstract
Aims: Determination of D variants is important for selection of blood products and to prevent anti-D-related hemolytic disease of the fetus and newborn. The prevalence of weak D phenotypes varies significantly among different ethnic populations. In Morocco, D variants have not been fully characterized. The purpose of this study was to determine prevalence of weak D among D negative and C/E+ blood donors and distribution of Rhesus blood group antigens using serologic methods.
Methods: A total of 15,865 blood samples from Moroccan blood donors were tested for D, C, c, E, e antigens by routine serologic methods. Among blood donors serologically D negative C+ and/or E+, 63 samples were tested for weak D by indirect antiglobuline test, enzymatic treated cells test and adsorption elution technique.
Results: Among 63 samples tested, 10 were positive by serologic methods (15.87%). Six samples identified as weak D by enzymatic test and four samples identified as Del by adsorption elution. Rhesus blood group antigens are distributed as DCcee: 38.85% and dccee :8.77%.
Conclusion: The prevalence of D variants must be considered in transfusional and obstetrical strategy for RhD typing to ensure blood transfusion safety by optimizing the management of D-negative RBC units and Rh immune globulins.

Keywords: Anti-D immunization, D variant, Moroccan population, RhD, RBC serology, Transfusion, Weak D phenotype


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Author Contributions:
Mariam EL Wafi – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Houria EL Housse – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Nadia Nourichafi – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Kamal Bouisk – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Mohamed Benajiba – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Norddine Habti – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of submission
The corresponding author is the guarantor of submission.
Source of support
None
Conflict of interest
Authors declare no conflict of interest.
Copyright
© 2016 Mariam EL Wafi et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.



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