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Induced pluripotent stem cells in infections
Anubha Singh1, Deepak Kumar Singh2, Usha Bhoria3
1Senior Resident, Department of Laboratory Services, Employees' State Insurance Corporation Model Hospital, Ministry of Labor, Noida, Uttar Pradesh, India.
2Junior Specialist, Department of Laboratory Services, Employees' State Insurance Corporation Model Hospital, Ministry of Labor, Noida, Uttar Pradesh, India.
3Senior Specialist, Department of Laboratory Services, Employees' State Insurance Corporation Model Hospital, Ministry of labor, Noida, Uttar Pradesh, India.

Article ID: 100017IJBTIAS2015
doi:10.5348/ijbti-2015-17-RA-3

Address correspondence to:
Anubha Singh
Senior Resident, Department of Laboratory Services, Employees' State Insurance Corporation Model Hospital
Noida, Uttar Pradesh
India

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How to cite this article
Singh A, Singh DK, Bhoria U. Application of induced pluripotent stem cells in infections. Int J Blood Transfus Immunohematol 2015;5:14–18.


Abstract
Regenerative medicine has an exciting role in the treatment of disorders and conditions where there is an irreversible damage to a tissue or an organ or in immunodeficient state. Stem cells which have the potential to differentiate into specific types of cells, offers a new concept of regenerative medicine to treat spectrum of diseases including infections. Infections are one of the cause of high morbidity during injuries and in immunodeficient states. Induced pluripotent stem cells (iPSCs) are generated by genetically reprogramming the adult cells to an embryonic stem cell (ESC)-like state by being forced to express genes and factors essential for maintaining the defining properties of ESC. In infections, eosinophils play an important role as they are potent source of cytotoxic mediators such as eosinophil cationic protein (ECP) and major basic proteins (MBP). These substances play an important role in immune response to infections caused by bacteria, viruses, parasites and in resistance to some forms of cancer. Strategies to enhance the intrinsic functional abilities of eosinophils by lineage specific differentiation of iPSC and enhanced expression of cytotoxic mediators by advanced genetic engineering approach provide important future application in such opportunistic infections.

Keywords: Induced pluripotent stem cell (iPSC), Reprogramming, Hematopoietic cells, infections, Eosinophils

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Author Contributions
Anubha Singh – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Deepak Kumar Singh – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Usha Bhoria – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of submission
The corresponding author is the guarantor of submission.
Source of support
None
Conflict of interest
Authors declare no conflict of interest.
Copyright
© 2015 Anubha Singh et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.



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