International Journal of Blood Transfusion and Immunohematology - IJBTI - Review Articles, Original Articles, Short Communication, Case Series, Case Reports, Letter to Editors
 
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Original Article
 
Correlation of umbilical cord blood volume with CD34+ cells concentration
Tulika Chandra1, Sheeba Afreen1, 2, Ashutosh Kumar2, Uma Singh3
1Department of Transfusion Medicine and Blood Bank, Chhatrapati Shahuji Maharaj Medical University (Earlier King Georg's Medical University), Lucknow Uttar Pradesh, India.
2Professor, Department of Pathology, Chhatrapati Shahuji Maharaj Medical University (Earlier King Georg's Medical University), Lucknow Uttar Pradesh, India.
3Professor, Department of Obstetrics and Gynecology, Chhatrapati Shahuji Maharaj Medical University (Earlier King Georg's Medical University), Lucknow Uttar Pradesh, India.

Article ID: 100003IJBTITC2011
doi:10.5348/ijbti-2011-3-OA-3

Address correspondence to:
Dr. Tulika Chandra
Assistant Professor, Department of Transfusion Medicine and Blood Bank
Chhatrapati Shahuji Maharaj Medical University
Lucknow, Uttar Pradesh
India
Phone: +91-9415755536
Email: tulikachandra@rediffmail.com

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How to cite this article:
Chandra T, Afreen S, Kumar A, Singh U. Correlation of umbilical cord blood volume with CD34+ cells concentration. International Journal of Blood Transfusion and Immunohematology 2011;1:12-16.


Abstract
Aims: Umbilical cord blood (UCB) has been recently considered as an alternative source of hematopoitic progenitor cells for clinical application. The parameters commonly used to evaluate a UCB unit and predict transplant outcomes have been total nucleated cell count (TNCs), CD34+ cells concentration and total volume of cord blood collected. The volume of cord blood collection is also important for the high yield of CD34+ cells concentration and TNCs. The aim of the study was to find the correlation of umbilical cord blood volume with cord blood derived CD34+ cells concentration.
Methods: Umbilical cord blood was collected from normal vaginal and cesarean deliveries. Total volume of cord blood collection was noted. It was immediately processed and assessed for total nucleated cells count and CD34+ cells concentration. Assessment of maternal and neonatal parameters such as mode of delivery, baby's birth weight and sex, cord blood volume and CD34+ cells concentration was made.
Results: Total volume of cord blood and CD34+ cells concentration positively correlated with cesarean delivery and higher birth weight of the baby (p<0.01). We also found that, CD34+ cells concentration was higher in greater volume of collected cord blood.
Conclusions: Our study concludes that higher volume of cord blood should be preferred for processing and stem cell infusion.

Key Words: CD34+ cells, TNC, Cord blood volume, Stem cells

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Author Contributions:
Tulika Chandra - Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Sheeba Afreen - Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Ashutosh Kumar - Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Uma Singh - Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of submission:
The corresponding author is the guarantor of submission.
Source of support:
None
Conflict of interest:
The authors have no conflicts of interest
Copyright:
© Tulika Chandra et al. 2011; This article is distributed the terms of Creative Commons attribution 3.0 License which permits unrestricted use, distribution and reproduction in any means provided the original authors and original publisher are properly credited. (Please see Copyright Policy for more information.)



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