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International Journal of Blood Transfusion and Immunohematology - IJBTI - Review Articles, Original Articles, Short Communication, Case Series, Case Reports, Letter to Editors
 
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Original Article
 
Survey of platelet glycoprotein specific antibodies and HLA class 1 antibodies in a cross section of Nigerian multiparous women
Zaccheaus Awortu Jeremiah1, Justina Egwuma Oburu2,
1Haematology and Blood Transfusion Unit, Department of Medical Laboratory Sciences, College of Health Sciences, Niger Delta University, Wilberforce Island, Bayelsa State, Nigeria.
2Department of Haematology and Blood Transfusion, University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria.


Article ID: 100002IJBTIZAJ2011
doi:10.5348/ijbti-2011-2-OA-2

Address correspondence to:
Zaccheaus Awortu Jeremiah
P.O.Box 1437, Diobu,
Port Harcourt 500001,
Rivers State,
Nigeria;
Phone: +234 (803) 404 5636;
Email: zacjerry@yahoo.com

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How to cite this article:
Jeremiah ZA, Oburu JE. Survey of platelet glycoprotein specific antibodies and HLA class 1 antibodies in a cross section of nigerian multiparous women. International Journal of Blood Transfusion and Immunohematology 2011;1:7-11.


Abstract
Aims: The frequencies of alloantibodies to platelet glycoproteins and HLA class 1 have not been reported in this part of the world. To determine the prevalence of these antibodies in Nigeria.
Methods: The sera of 100 multiparous women were tested for antibodies to HPA and HLA class 1 antigens using GTI PakPlus solid phase ELISA Kit in a cross sectional study.
Results: The prevalence of platelet glycoproteins specific antibodies was obtained as follows: GP IIb/IIIa (10%), GP Ia/IIa (48%), GP IV (8%) and GP Ib/IX (12%). Further analysis revealed the prevalence of each platelet antibody subgroup as follows: anti-HPA-1a,-3a,-4a (0%), anti-HP-1b,-3a,-4a (10%), anti-HPA-5a (18%), anti-HPA-5b (30%). HLA class 1 antibody was prevalent in 22% cases. The production of these antibodies was parity dependent.
Conclusions: There is a high prevalence of anti-HPA-5b and anti-HLA class 1 in our female population which can pose potential threat to our blood donor pool.

Key Words: Platelet glycoproteins, Platelet antibodies, HLA class 1 antibodies, Multiparous women, Nigeria

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Author Contributions:
Zaccheaus Awortu Jeremiah - Substantially contributed to conception and design, acquisition of data , drafting the article, revising it critically for important intellectual content and final approval of the version to be published
Justina Egwuma Oburu - Contributed tto conception and design, analysis and interpretation of data and final approval of the version to be published
Guarantor of submission:
The corresponding author is the guarantor of submission.
Source of support:
None
Conflict of interest:
Authors declare no conflict of interest.
Copyright:
© Zaccheaus Awortu Jeremiah et al. 2011; This article is distributed the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any means provided the original authors and original publisher are properly credited. (Please see Copyright Policy for more information.)



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