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International Journal of Blood Transfusion and Immunohematology - IJBTI - Review Articles, Original Articles, Short Communication, Case Series, Case Reports, Letter to Editors
 
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Original Article
 
Evaluation of the clinical utility of maternal alloantibody screening as a surrogate to antiglobulin crossmatch procedures in resource limited settings
Zaccheaus Awortu Jeremiah1, Augustina Mordi2,
1Haematology and Blood Transfusion Unit, Department of Medical Laboratory Sciences, College of Health Sciences, Niger Delta University, Wilberforce Island, Bayelsa State;
2Medical Laboratory Services Department, Braithwait Memorial Specialist Hospital, Port Harcourt, Nigeria.


Article ID: 10001IJBTIJZA2011
doi: 10.5348/ijbti-2011-1-OA-1

Address correspondence to:
Zaccheaus Awortu Jeremiah
P.O. Box 1 437 Diobu, Port Harcourt 500001
Rivers State
Nigeria
+234 (803) 404 5636;
Email: zacjerry@yahoo.com

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How to cite this article:
Jeremiah ZA, Mordi A. Evaluation of the clinical utility of maternal alloantibody screening as a surrogate to antiglobulin crossmatch procedures in resource limited settings. International Journal of Blood Transfusion and Immunohematology 2011;1:1-6.


Abstract
Aims: In resource limited settings, cross matching procedures are usually limited to the conventional antiglobulin technique. Pre-transfusion screening for red cell alloantibodies are not carried out routinely. The study was aimed at evaluating the usefulness of antibody screening as a surrogate to antiglobulin crossmatch procedure.
Methods: A total 250 pregnant women attending the antenatal clinic of the Braithwaite Memorial Specialist Hospital (BMSH), Port Harcourt were screened for the presence of red cell alloantibodies using DiaMed screening and panel cells (DiaCell and DiaPanels).
Results: Alloantibodies detected were anti-E (1.2%), anti-K (0.8%), anti-C (0.4%) and anti-Jsb (0.4%). The overall prevalence rate of red cell allo - antibodies was 4.8%. A blind crossmatch performed using the serum of the patients on donor's cells revealed the following results—incompatible 5 (2.0%) and 254 (98.0%) compatible. Taking incompatible results as positive and compatible as negative, the performance indices of the antibody screening procedure was obtained as follows: sensitivity (41.6%), specificity (100%), PPV (100%), NPV (97.1%), Efficiency (48.6%). Prevalence (4.8%) and percentage safety (41 .6%). The study did not show the type and screen to reach the expected safety level of 99.0%. Its usefulness was however shown through the detection of unexpected antibodies in 4.8% of the subjects.
Conclusions: We concluded that with a high specificity obtained, the detection and identification of these antibodies would help select blood in advance for patients undergoing surgery in order to reduce the incidence of haemolytic transfusion reactions.

Key Words: Antibody screening, Antiglobulin crossmatch, Pretransfusion testing, Antibody identification

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Author Contributions:
Zaccheaus Awortu Jeremiah - substantially contributed to conception and design, acquisition of data , drafting the article, revising it critically for important intellectual content and final approval of the version to be published
Augustina Mordi - contributed tto conception and design, analysis and interpretation of data and final approval of the version to be published
Guarantor of submission:
The corresponding author is the guarantor of submission.
Source of support:
None
Conflict of interest:
Authors declare no conflict of interest.
Copyright:
© Zaccheaus Awortu Jeremiah et al. 2011; This article is distributed the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any means provided the original authors and original publisher are properly credited. (Please see Copyright Policy for more information.)



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